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Ethyl 4-chloroacetoacetate is an important -keto ester widely used as a versatile intermediate in organic and pharmaceutical synthesis. It contains both an active methylene group and a reactive chloro substituent, making it highly useful for alkylation, cyclization, and heterocycle-forming reactions. The compound is commonly employed in the preparation of substituted acetoacetic acid derivatives, agrochemical intermediates, dyes, and APIs, particularly where chlorinated building blocks are required to introduce further functional groups. Owing to its reactivity and synthetic flexibility, it is valued in fine chemicals and medicinal chemistry research.
Synonyms: Ethyl 4-chloro-3-oxobutanoate; Ethyl chloroacetoacetate; 4-Chloroacetoacetic acid ethyl ester; Ethyl chloroacetoacetate ester.



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