1- HYDOXYBENZOTRIAZOLE ANHYDROUS (HOBT)

1- HYDOXYBENZOTRIAZOLE ANHYDROUS (HOBT) About

1-Hydroxybenzotriazole anhydrous (HOBt) is a heterocyclic organic compound widely used as a coupling additive in peptide synthesis and other amide-bond-forming reactions. It improves reaction efficiency by suppressing racemization and enhancing coupling yields, especially when used with carbodiimides such as DCC or EDC. HOBt anhydrous is the water-free form, preferred for moisture-sensitive reactions and better reproducibility. Synonyms include 1-Hydroxy-1H-benzotriazole, Hydroxybenzotriazole, HOBt, and HoBt (anhydrous). Applications of HOBt extend beyond peptide synthesis to pharmaceutical intermediate manufacturing, combinatorial chemistry, solid-phase synthesis, and fine chemical research, where controlled and efficient amide formation is required.