1- HYDOXYBENZOTRIAZOLE MONOHYDRATE

1- HYDOXYBENZOTRIAZOLE MONOHYDRATE About

1-Hydroxybenzotriazole monohydrate is a heterocyclic organic compound widely used as a coupling additive in peptide and amide bond formation, valued for its ability to suppress racemization and improve reaction efficiency. It typically appears as a white to off-white crystalline solid, with the monohydrate form offering improved stability and safer handling compared to the anhydrous material. Common synonyms include HOBt monohydrate, 1-hydroxy-1H-benzotriazole hydrate, and benzotriazol-1-ol monohydrate. In terms of applications, it is extensively used in peptide synthesis, pharmaceutical research, and fine chemical manufacturing, particularly in combination with carbodiimide coupling reagents to enhance yields and purity of amide-linked products.